Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis
Abstract
To elucidate the genetic architecture of amyotrophic lateral sclerosis (ALS) and find associated loci, we assembled a custom imputation reference panel from whole-genome-sequenced patients with ALS and matched controls (n = 1,861). Through imputation and mixed-model association analysis in 12,577 cases and 23,475 controls, combined with 2,579 cases and 2,767 controls in an independent replication cohort, we fine-mapped a new risk locus on...
Paper Details
Title
Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis
Published Date
Jul 25, 2016
Journal
Volume
48
Issue
9
Pages
1043 - 1048
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