RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation

Objective

Serrated polyps (hyperplastic polyps, sessile or traditional serrated adenomas), which can arise in a sporadic or polyposis setting, predispose to colorectal cancer (CRC), especially those with microsatellite instability (MSI) due to MLH1 promoter methylation (MLH1^me+). We investigate genetic alterations in the serrated polyposis pathway.

Design

We used a combination of exome sequencing and target gene...