miR-106b-5p and miR-17-5p suppress osteogenic differentiation by targeting Smad5 and inhibit bone formation

Osteogenesis is a complex process which relies on the coordination of signals and transcription factors. BMP-2/Smad5 signal transduction pathway plays an important role in the process. Recent evidence indicates that microRNAs (miRNAs) act as important post-transcriptional regulators in a large number of biological processes including osteoblast differentiation. In this study, we investigated the effect of miR-106b-5p and miR-17-5p on osteogenic...