Efficient and scalable synthesis of α,α-disubstituted β-amino amides

Volume: 14, Issue: 31, Pages: 7570 - 7578
Published: Jan 1, 2016
Abstract
A practical and efficient methodology for the preparation of 2-aminoethyl α,α-disubstituted β-amino amides in three steps from methyl cyanoacetate has been developed. The key step in the synthesis was the chemoselective reduction of the nitrile group in presence of an amide and aryl halide functionalities. Reduction with RANEY® Nickel catalyst, either with molecular hydrogen (8-10 bar) or under transfer hydrogenation conditions, necessitated in...
Paper Details
Title
Efficient and scalable synthesis of α,α-disubstituted β-amino amides
Published Date
Jan 1, 2016
Volume
14
Issue
31
Pages
7570 - 7578
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