Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing
Abstract
The cyclin-dependent kinase inhibitor p21(WAF1/CIP1) (p21) is a cell-cycle checkpoint effector and inducer of senescence, regulated by p53. Yet, evidence suggests that p21 could also be oncogenic, through a mechanism that has so far remained obscure. We report that a subset of atypical cancerous cells strongly expressing p21 showed proliferation features. This occurred predominantly in p53-mutant human cancers, suggesting p53-independent...
Paper Details
Title
Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing
Published Date
Jun 20, 2016
Journal
Volume
18
Issue
7
Pages
777 - 789
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