Tumor Tension Induces Persistent Inflammation and Promotes Breast Cancer Aggression

: Human breast tumors are highly fibrotic and their ECMs are stiffer relative to benign lesions. More recently, we established positive correlations between the number and location of infiltrating immune cells and ECM stiffness in human breast tumors. This has led us to hypothesize that TAMs drive tissue fibrosis and subsequently may stimulate inflammatory signaling. Using the MMTV-PyMT model, early macrophage not only ablated lung metastases,...