Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy
Abstract
Single-agent immunotherapy has achieved limited clinical benefit to date in patients with pancreatic ductal adenocarcinoma (PDAC). This may be a result of the presence of a uniquely immunosuppressive tumor microenvironment (TME). Critical obstacles to immunotherapy in PDAC tumors include a high number of tumor-associated immunosuppressive cells and a uniquely desmoplastic stroma that functions as a barrier to T cell infiltration. We identified...
Paper Details
Title
Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy
Published Date
Jul 4, 2016
Journal
Volume
22
Issue
8
Pages
851 - 860
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History