Regulation of GnRH receptor gene expression in sheep and cattle.

The GnRH receptor plays a pivotal role in reproduction. This review summarizes current knowledge of the regulation of GnRH receptor gene expression by endocrine factors in sheep and cattle. Expression of the GnRH receptor gene, measured by steady-state amounts of GnRH receptor messenger RNA (mRNA), is maximal during the preovulatory period. The molecular events leading to maximal GnRH receptor gene expression are probably triggered by decreased...