Original paper

UMI-4C for quantitative and targeted chromosomal contact profiling

Volume: 13, Issue: 8, Pages: 685 - 691
Published: Jul 4, 2016
Abstract
We developed a targeted chromosome conformation capture (4C) approach that uses unique molecular identifiers (UMIs) to derive high-complexity quantitative chromosome contact profiles with controlled signal-to-noise ratios. UMI-4C detects chromosomal interactions with improved sensitivity and specificity, and it can easily be multiplexed to allow robust comparison of contact distributions between loci and conditions. This approach may open the...
Paper Details
Title
UMI-4C for quantitative and targeted chromosomal contact profiling
Published Date
Jul 4, 2016
Volume
13
Issue
8
Pages
685 - 691
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