Virus-like particle-based vaccine against coxsackievirus A6 protects mice against lethal infections
Abstract
Coxsackievirus A6 (CA6) is emerging as one of the major causative agents of hand, foot, and mouth disease (HFMD) worldwide. However, no vaccine is currently available for preventing CA6 infection. Here, we report the development of a virus-like particle (VLP)-based recombinant vaccine for CA6. We produced CA6 VLPs in insect cells by infecting the cells with a baculovirus coexpressing the genes encoding CA6 P1 and 3CD. Biochemical analyses showed...
Paper Details
Title
Virus-like particle-based vaccine against coxsackievirus A6 protects mice against lethal infections
Published Date
Jul 1, 2016
Journal
Volume
34
Issue
34
Pages
4025 - 4031
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