Cbl-b promotes cell detachment via ubiquitination of focal adhesion kinase
Abstract
Cancer cell detachment from the primary tumor site represents the first stage of metastasis. Previous studies have identified that cell detachment is triggered by cytoskeletal disruption, which may induce a wide variety of cellular changes. Focal adhesion kinase (FAK) exhibits crucial cellular functions, including regulation of the cytoskeleton. These observations have provided exciting insights into the effect of FAK in cell detachment;...
Paper Details
Title
Cbl-b promotes cell detachment via ubiquitination of focal adhesion kinase
Published Date
Jun 15, 2016
Journal
Volume
12
Issue
2
Pages
1113 - 1118
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