Dynamic tensile forces drive collective cell migration through three-dimensional extracellular matrices
Abstract
Collective cell migration drives tissue remodeling during development, wound repair, and metastatic invasion. The physical mechanisms by which cells move cohesively through dense three-dimensional (3D) extracellular matrix (ECM) remain incompletely understood. Here, we show directly that migration of multicellular cohorts through collagenous matrices occurs via a dynamic pulling mechanism, the nature of which had only been inferred previously in...
Paper Details
Title
Dynamic tensile forces drive collective cell migration through three-dimensional extracellular matrices
Published Date
Jul 13, 2015
Journal
Volume
5
Issue
1
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