Epigenetic silencing of the MUPCDH gene as a possible prognostic biomarker for cyst growth in ADPKD

Although autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disease and is characterized by the formation of multiple fluid-filled cysts, which results in renal failure, early diagnosis and treatment of ADPKD have yet to be defined. Herein, we observed that the promoter region of the gene encoding mucin-like protocadherin ( MUPCDH ) was hypermethylated in the renal tissue of patients with ADPKD compared to non-ADPKD...