A BH3 Mimetic for Killing Cancer Cells
Abstract
Venetoclax is a BH3 mimetic approved for treating chronic lymphocytic leukemia. Cancer cells are resistant to apoptosis but "primed for death" by elevated BCL-2, which binds to pro-apoptotic proteins and holds them in check. Venetoclax releases this antagonism and is the first approved drug to target a protein-protein...
Paper Details
Title
A BH3 Mimetic for Killing Cancer Cells
Published Date
Jun 1, 2016
Journal
Volume
165
Issue
7
Pages
1560 - 1560
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Notes
History