Quantitative assessment of the effects of water proton concentration and water T 1 changes on amide proton transfer ( APT ) and nuclear overhauser enhancement ( NOE ) MRI : The origin of the APT imaging signal in brain tumor
Abstract
To quantify pure chemical exchange-dependent saturation transfer (CEST) related amide proton transfer (APT) and nuclear Overhauser enhancement (NOE) signals in a rat glioma model and to investigate the mixed effects of water content and water T1 on APT and NOE imaging signals.Eleven U87 tumor-bearing rats were scanned at 4.7 T. A relatively accurate mathematical approach, based on extrapolated semisolid magnetization-transfer reference signals,...
Paper Details
Title
Quantitative assessment of the effects of water proton concentration and water T 1 changes on amide proton transfer ( APT ) and nuclear overhauser enhancement ( NOE ) MRI : The origin of the APT imaging signal in brain tumor
Published Date
Feb 2, 2016
Volume
77
Issue
2
Pages
855 - 863
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