Incipient Melanoma Brain Metastases Instigate Astrogliosis and Neuroinflammation
Abstract
Malignant melanoma is the deadliest of skin cancers. Melanoma frequently metastasizes to the brain, resulting in dismal survival. Nevertheless, mechanisms that govern early metastatic growth and the interactions of disseminated metastatic cells with the brain microenvironment are largely unknown. To study the hallmarks of brain metastatic niche formation, we established a transplantable model of spontaneous melanoma brain metastasis in...
Paper Details
Title
Incipient Melanoma Brain Metastases Instigate Astrogliosis and Neuroinflammation
Published Date
Aug 1, 2016
Journal
Volume
76
Issue
15
Pages
4359 - 4371
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Notes
History