Direct contact with perivascular tumor cells enhances integrin αvβ3 signaling and migration of endothelial cells

Volume: 7, Issue: 28, Pages: 43852 - 43867
Published: May 30, 2016
Abstract
The secretion of soluble pro-angiogenic factors by tumor cells and stromal cells in the perivascular niche promotes the aggressive angiogenesis that is typical of glioblastoma (GBM). Here, we show that angiogenesis also can be promoted by a direct interaction between brain tumor cells, including tumor cells with cancer stem-like properties (CSCs), and endothelial cells (ECs). As shown in vitro, this direct interaction is mediated by binding of...
Paper Details
Title
Direct contact with perivascular tumor cells enhances integrin αvβ3 signaling and migration of endothelial cells
Published Date
May 30, 2016
Journal
Volume
7
Issue
28
Pages
43852 - 43867
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