[Immunogenicity studies in experimental animals immunized with a low-molecular antigen alone and the antigen plus adjuvants].

The present studies were undertaken to clarify the immunogenicity evoked in four species, the guinea pig, rabbit, F344 rat and A/J mouse, immunized with a low-molecular antigen (TNBS) alone, TNBS plus Alum and TNBS plus FCA. Each species was divided into three groups: TNBS alone sc group, TNBS plus Alum ip groups (one and 3 times sensitization) and TNBS plus FCA sc groups (one and 3 times sensitization), and immune responses to TNBS were...