In vivo and in vitro antimicrobial activity of silver sulfadiazine and cerium nitrate.

Published on Aug 1, 1980in Surgery gynecology & obstetrics
Saffer Ld2
Estimated H-index: 2
,
George T. Rodeheaver53
Estimated H-index: 53
+ 1 AuthorsRichard F. Edlich57
Estimated H-index: 57
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Abstract
: The antimicrobial activity of cerium nitrate and silver sulfadiazine was assessed in vitro and in vivo using Pseudomonas aeruginosa. In vitro, the activity of silver sulfadiazine was significantly greater than that of cerium nitrate. Synergism between silver sulfadiazine and cerium nitrate was observed in water or saline solution suspensions, but not in broth. In vivo, cerium nitrate offered no therapeutic benefit in reducing wound infection in contaminated wounds. Treatment of similar wounds with silver sulfadiazine resulted in a significant decrease in wound infection and in the level of viable bacteria when compared with that for untreated controls. The addition of cerium nitrate to silver sulfadiazine in aqueous soultion reduced the therapeutic benefit of silver sulfadiazine.
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References0
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Cited By13
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#1An-Rong Lee (NDMC: National Defense Medical Center)H-Index: 11
#2Wen-Hsin Huang (NDMC: National Defense Medical Center)H-Index: 10
Two new zinc sulphadiazine (Zn(SD) 2 )-amine complexes, zinc sulphadiazine-methylamine (Zn(SD) 2 (CH 3 NH 2 ) 2 ) and zinc sulphadiazine-ethylenediamine (Zn(SD) 2 (C 2 HgN 2 ) 3 .H 2 O), were prepared and compared with silver sulphadiazine (AgSD). The compounds were readily obtained by reaction of zinc nitrate hexahydrate with sulphadiazine or its salt in methylamine and ethylenediamine, respectively. Structure was established by X-ray crystallography and ultraviolet-visible, infrared and nuclea...
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Abstract Background: The introduction of early excision of the burn eschar has contributed to a reduction in burn-related mortality but is not appropriate in all circumstances. Cerium nitrate has been used since 1976, usually in combination with silver sulphadiazine, to improve outcome where early excision is not performed. However, has still not gained universal acceptance. The evidence for its use is reviewed. Methods: A MEDLINE search was performed for the years 1966–2003 using keywords ‘ceri...
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#1Michael A. Jakupec (University of Vienna)H-Index: 71
#2Peter Unfried (University of Vienna)H-Index: 9
Last. Bernhard K. Keppler (University of Vienna)H-Index: 98
view all 3 authors...
Cerium is a member of the lanthanide series or rare earth elements which exert diverse biological effects mainly by their resemblance to calcium. This similarity, which is particularly characteristic for the lighter members of the lanthanide series, enables these elements to replace calcium in biomolecules without necessarily substituting for it functionally. While the inhibitory effects on calcium-dependent physiological processes (such as those involved in the blood clotting cascade as well as...
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Background– Fundermol is a topical agent for partial-thickness burns. Silver sulphadiazine is a topical agent for treatment of burn wounds. The aim of this study was to compare the efficacy of silver sulphadiazine dressing versus fundermol for burn healing and consequently prevention of infection in rats. Methods– Eighty-four Albino NMRI rats were scalded with boiling water for 6 seconds, resulting in second degree burns involving 10% total body surface area (TBSA). The rats were randomly divide...
Abstract Cerium is used for its antiseptic and immunomodulatory properties in burn injury. We have developed a cerium-doped clay to replace existing ointments. Adsorption and release of cerium (Ce 3+ ) by diosmectite were studied at 22±2°C, in the presence of various other cationic species. Simple spectrofluorimetric determination of cerium was used ( λ exc=240 nm/ λ em=360 nm). Cerium binding reached a plateau within 2 min and was a function of the electrolyte content of the solution in contact...
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#1C. H. Evans (University of Pittsburgh)H-Index: 1
Metals have been used medicinally since antiquity; the ancient Chinese, for instance, ascribed therapeutic properties to gold. It is likely that Ekeberg, in 1797, was the first to suggest such an application for a rare earth. As Pyykko and Orama describe in Chapter 1 of this volume, after repeating Gadolin’s isolation of the new earth yttria Ekeberg noted that it had a sweet taste “almost like that of lead compounds but not so repulsive but rather contracting” and suggested that it could be “med...
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#1W Boeckx (CUA: The Catholic University of America)H-Index: 1
#2Phillip Blondeel (CUA: The Catholic University of America)H-Index: 53
Last. A Schmitz (CUA: The Catholic University of America)H-Index: 1
view all 5 authors...
Abstract Although there are excellent clinical results from using cerium nitrate plus silver sulphadiazine in the treatment of deep dermal burns in our burn centre, its mechanism of action remains unexplained. We set up a prospective study to establish a hypothesis which could explain the formation of the typical leathery crust. Burns treated with cerium nitrate plus silver sulphadiazine and silver sulphadiazine alone were compared histologically and metallurgically. Application of cerium nitrat...
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#1C. H. Evans (University of Pittsburgh)H-Index: 1
Many of the properties of the lanthanides appear to lend themselves to clinical application. The lanthanides are antimicrobial and anticoagulant substances which suppress many of the types of Ca2+-dependent cellular activation processes (Section 6.4) that occur in diseases. Lanthanides are of relatively low toxicity (Chapter 8), while their metabolism can be manipulated by the presence of specific chelators, by varying the site of injection, or both (Chapter 7). In addition, lanthanides appear t...
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#1C. H. Evans (University of Pittsburgh)H-Index: 1
Broadly speaking, lanthanides interfere with normal metabolism in one of two general ways. The first is through specific biochemical interaction producing, as we shall see, a variety of toxic and pharmacologic sequelae. The second concerns the damage inflicted by radioactive lanthanides. Although the latter is an important matter related to such topical concerns as the safety of nuclear power plants and the dangers of nuclear weapons, it is not, in itself, a field of inquiry that is unique to th...
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#1Berry Jp (French Institute of Health and Medical Research)H-Index: 9
#2R. MasseH-Index: 2
Last. Pierre Galle (French Institute of Health and Medical Research)H-Index: 14
view all 4 authors...
Radioactive cerium is a nuclear toxicant. Metallic cerium is used in industry. Aspects of the intracellular metabolism of this element were studied following intraperitoneal injection and aerosol exposure in rat. Two microanalytic methods, an electron microprobe and ionic microanalysis, enabled the sites of incorporation and the process of intracellular concentration of cerium to be determined in the liver, lung, kidney, bone marrow and bone tissue. The very high sensitivity of ionic analysis en...
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