Design of a genetic immunotoxin to eliminate toxin immunogenicity.
Abstract
Host antibody response to toxin molecules is a major obstacle to the use of immunotoxins as efficacious agents in the treatment of human cancer and other diseases. In this study, a genetic form of immunotoxin has been designed which should eliminate toxin immunogenicity by replacing the toxin protein moiety with weakly immunogenic or nonimmunogenic plasmid DNA. A recombinant bifunctional fusion protein, which consists of a human antibody Fab...
Paper Details
Title
Design of a genetic immunotoxin to eliminate toxin immunogenicity.
Published Date
Mar 1, 1995
Journal
Volume
2
Issue
2
Pages
116 - 23
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Notes
History