Transcriptional repression of p27 is essential for murine embryonic development
Abstract
The Nczf gene has been identified as one of Ncx target genes and encodes a novel KRAB zinc-finger protein, which functions as a sequence specific transcriptional repressor. In order to elucidate Nczf functions, we generated Nczf knockout (Nczf-/-) mice. Nczf-/- mice died around embryonic day 8.5 (E8.5) with small body size and impairment of axial rotation. Histopathological analysis revealed that the cell number decreased and pyknotic cells were...
Paper Details
Title
Transcriptional repression of p27 is essential for murine embryonic development
Published Date
May 19, 2016
Journal
Volume
6
Issue
1
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