Abstract B2-10: Systems biology reveals role of cholesterol homeostasis in breast cancer metastasis
Abstract
New therapeutic targets that can inhibit cancer metastasis are desperately needed. To address this issue, we have leveraged a computational approach and performed an unbiased screen for therapies that can inhibit an epithelial-to-mesenchymal transition (EMT) gene expression profile, a phenotype that is believed to promote metastases. This yielded predictions of drugs that can both promote and inhibit an EMT transcriptional profile. Following up...
Paper Details
Title
Abstract B2-10: Systems biology reveals role of cholesterol homeostasis in breast cancer metastasis
Published Date
Nov 15, 2015
Journal
Volume
75
Issue
22_Supplement_2
Pages
B2 - 10
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