Antibacterial Activity of Silver Nanoparticle-Loaded Soft Contact Lens Materials: The Effect of Monomer Composition

Published on May 21, 2016in Current Eye Research1.754
· DOI :10.3109/02713683.2015.1123726
Maryam Shayani Rad8
Estimated H-index: 8
(MUMS: Mashhad University of Medical Sciences),
Bahman Khameneh15
Estimated H-index: 15
(MUMS: Mashhad University of Medical Sciences)
+ 2 AuthorsBibi Sedigheh Fazly Bazzaz22
Estimated H-index: 22
(MUMS: Mashhad University of Medical Sciences)
ABSTRACTPurpose: In the present work, the effect of monomer composition on silver nanoparticles’ (SNPs) binding capacity of hydrogels was investigated and their antibacterial efficacy was evaluated.Materials and methods: Three series of poly-hydroxyethyl methacrylate (HEMA) hydrogels were prepared using methacrylic acid (MAA), methacrylamide (MAAM), and 4-vinylpyridine (4VP) as co-monomers, and ethylene glycol dimethacrylate (EGDMA) as cross-linker. SNPs binding capacity of hydrogels was evaluated in different concentrations (2, 10, and 20 ppm). In vitro antibacterial activity of SNP-loaded hydrogels was studied against Pseudomonas aeruginosa (P. aeruginosa) isolated from patients’ eyes. Then, inhibitory effect of hydrogels in biofilm formation was evaluated in the presence of Staphylococcus epidermidis (S. epidermidis) (DSMZ 3270).Results: Our data indicated that poly(HEMA-co-MAA-co-EGDMA) had superior binding affinity for SNPs in comparison with other hydrogels. All SNP-loaded hydrogels demonstrated exc...
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