Epidermal growth factor activation of NF-κb is mediated through IκBα degradation and intracellular free calcium

Volume: 16, Issue: 16, Pages: 2095 - 2102
Published: Apr 23, 1998
Abstract
The transcription factor NF-kappa-B is normally sequestered in the cytoplasm by its inhibitory subunit IkappaB. Most extracellular signals activate NF-kappa-B through a mechanism involving the phosphorylation and proteasome-dependent degradation of IkappaB. EGF activates NF-kappaB in A-431 carcinoma cells, which overexpress EGF receptors and in mouse embryo fibroblasts, which have a normal complement of receptors. Supershift experiments indicate...
Paper Details
Title
Epidermal growth factor activation of NF-κb is mediated through IκBα degradation and intracellular free calcium
Published Date
Apr 23, 1998
Journal
Volume
16
Issue
16
Pages
2095 - 2102
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