SIRT2 regulates insulin sensitivity in insulin resistant neuronal cells
Volume: 474, Issue: 4, Pages: 747 - 752
Published: Jun 1, 2016
Abstract
Insulin resistance in brain is well-associated with pathophysiology of deficits in whole-body energy metabolism, neurodegenerative diseases etc. Among the seven sirtuins, SIRT2 is the major deacetylase expressed in brain. Inhibition of SIRT2 confers neuroprotection in case of Parkinson's disease (PD) and Huntington's disease (HD). However, the role of this sirtuin in neuronal insulin resistance is not known. In this study, we report the role of...
Paper Details
Title
SIRT2 regulates insulin sensitivity in insulin resistant neuronal cells
Published Date
Jun 1, 2016
Volume
474
Issue
4
Pages
747 - 752
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