Effects of PI3-K/AKT signal transduction pathway in rat neural stem cells
Abstract
Objective To incubate rat neural stem cells(NSCs) with selection-specific inhibitor(LY294002) of PI3-K,and explore the effects of PI3-K/AKT signal transduction pathway in NSCs. Methods NSCs derived from E15-16 rats were isolated and cultured.After incubation of NSCs with different concentrations of LY294002(0 to 40 μmol/L),cell survival(WTS-8 assay),proliferation(BrdU immunohistochemical identification),differentiation(β...
Paper Details
Title
Effects of PI3-K/AKT signal transduction pathway in rat neural stem cells
Published Date
Jan 1, 2009
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