Effect of tyrosine kinase inhibitor emodin on VEGF receptors and its inhibitory effect on human colon cancer cells
Abstract
[Objective] To evaluate the anti-angiogenesis effect of emodin and its inhibitory effect on tyrosine kinase phosphorylation of vascular endothelium growth factor receptors(VEGFRs) in colon cancer cells.[Methods] Effect of emodin on VEGFR phosphorylation in colon cancer cells was tested by tyrosine kinase activity assay and western blot.Anti-proliferative and apoptotic effect of emodin on colon cancer cell lines was evaluated by soft agar colony...
Paper Details
Title
Effect of tyrosine kinase inhibitor emodin on VEGF receptors and its inhibitory effect on human colon cancer cells
Published Date
Jan 1, 2005
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