Therapeutic anti-CD3 monoclonal antibodies: from bench to bedside

Volume: 8, Issue: 8, Pages: 889 - 906
Published: May 10, 2016
Abstract
The induction of tolerance is a major goal of immunotherapy. Investigations over the last 20 years have shown that anti-CD3 monoclonal antibodies (mAbs) effectively treat autoimmune disease in animal models and have also shown promise in clinical trials. Tolerance induction by anti-CD3 mAbs is related to the induction of Tregs that control pathogenic autoimmune responses. Here, we review preclinical and clinical studies in which intravenous or...
Paper Details
Title
Therapeutic anti-CD3 monoclonal antibodies: from bench to bedside
Published Date
May 10, 2016
Volume
8
Issue
8
Pages
889 - 906
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