The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes
Abstract
The genomic landscape of breast cancer is complex, and inter- and intra-tumour heterogeneity are important challenges in treating the disease. In this study, we sequence 173 genes in 2,433 primary breast tumours that have copy number aberration (CNA), gene expression and long-term clinical follow-up data. We identify 40 mutation-driver (Mut-driver) genes, and determine associations between mutations, driver CNA profiles, clinical-pathological...
Paper Details
Title
The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes
Published Date
May 10, 2016
Journal
Volume
7
Issue
1
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