The role of DNA methylation in the expression of parathyroid hormone-related protein in humoral hypercalcemia of malignancy
Abstract
Hypercalcaemia is a complication in approximately 10% of malignant disorders and is particularly common in patients with tumours of epithelial origin [l]. In a ,high proportion of these patients the hypercalcaemia is due to the production of parathyroid hormone-related protein (PTHrP) [2]. This peptide has strong homology to PTH at the N-terminus [3] and closely mimics the action of PTH by binding to the same receptor [4]. Since the isolation of...
Paper Details
Title
The role of DNA methylation in the expression of parathyroid hormone-related protein in humoral hypercalcemia of malignancy
Published Date
Feb 1, 1993
Volume
21
Issue
1
Pages
11S - 11S
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