Significance of PI3K/Akt signal in apoptotic cells mimic Alzheimer's disease and the influence of edaravone

Objective To investigate the effects of edaravone(MCI-186)on apoptosis of PC12 cells induced by β-amyloid(Aβ)and its possible relationship with PI3K/Akt.Methods The flow cytometry analysis was used to detect apoptosis,and Western blot was used to detect Akt phosphorylation level and total Akt for observing the protective effect of MCI-186 on Aβ induced apoptosis in PC12 cells.Results Akt Ser473 decreased in group of model at different time...