Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells
Abstract
Pancreatic β cell dysfunction, i.e., failure to provide insulin in concentrations sufficient to control blood sugar, is central to the etiology of all types of diabetes. Current evidence implicates mitochondrial oxidative stress and endoplasmic reticulum (ER) stress in pancreatic β cell loss and impaired insulin secretion. Oxidative and ER stress are interconnected so that misfolded proteins induce reactive oxygen species (ROS) production;...
Paper Details
Title
Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells
Published Date
Aug 1, 2016
Journal
Volume
28
Issue
8
Pages
1099 - 1104
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