Identifying the antiasthmatic target of doxofylline using immobilizedβ2-adrenoceptor based high-performance affinity chromatography and site-directed molecular docking

Volume: 29, Issue: 10, Pages: 492 - 498
Published: May 12, 2016
Abstract
As a xanthine derivative, doxofylline is believed to be dominant for fighting against asthma in practice. Unlike other xanthines, the antiasthmatic effects of doxofylline lack any definite proof of target and mediating mechanism according to previous reports. In this work, the interaction between doxofylline and β2-AR was investigated by high performance affinity chromatography using frontal analysis and nonlinear model. The methodology involved...
Paper Details
Title
Identifying the antiasthmatic target of doxofylline using immobilizedβ2-adrenoceptor based high-performance affinity chromatography and site-directed molecular docking
Published Date
May 12, 2016
Volume
29
Issue
10
Pages
492 - 498
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