Human neutrophil kinetics: modeling of stable isotope labeling data supports short blood neutrophil half-lives
Abstract
Human neutrophils have traditionally been thought to have a short half-life in blood; estimates vary from 4 to 18 hours. This dogma was recently challenged by stable isotope labeling studies with heavy water, which yielded estimates in excess of 3 days. To investigate this disparity, we generated new stable isotope labeling data in healthy adult subjects using both heavy water (n = 4) and deuterium-labeled glucose (n = 9), a compound with more...
Paper Details
Title
Human neutrophil kinetics: modeling of stable isotope labeling data supports short blood neutrophil half-lives
Published Date
Jun 30, 2016
Journal
Volume
127
Issue
26
Pages
3431 - 3438
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