Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels
Abstract
Nicotinic acetylcholine, serotonin type 3, γ-amminobutyric acid type A, and glycine receptors are major players of human neuronal communication. They belong to the family of pentameric ligand-gated ion channels, sharing a highly conserved modular 3D structure. Recently, high-resolution structures of both open- and closed-pore conformations have been solved for a bacterial, an invertebrate, and a vertebrate receptor in this family. These data...
Paper Details
Title
Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels
Published Date
May 1, 2016
Journal
Volume
90
Issue
3
Pages
452 - 470
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