The redox protein p66shc mediates cochlear vascular dysfunction and transient noise-induced hearing loss
Abstract
p66 shc , a member of the ShcA protein family, is essential for cellular response to oxidative stress, and elicits the formation of mitochondrial Reactive Oxygen Species (ROS), thus promoting vasomotor dysfunction and inflammation. Accordingly, mice lacking the p66 isoform display increased resistance to oxidative tissue damage and to cardiovascular disorders. Oxidative stress also contributes to noise-induced hearing loss (NIHL); we found that...
Paper Details
Title
The redox protein p66shc mediates cochlear vascular dysfunction and transient noise-induced hearing loss
Published Date
May 9, 2016
Journal
Volume
6
Issue
1
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