High-resolution 18F-FDG PET/CT for assessing disease activity in rheumatoid and psoriatic arthritis: findings of a prospective pilot study

Published on May 11, 2016in British Journal of Radiology2.196
· DOI :10.1259/BJR.20160138
Abhijit J. Chaudhari18
Estimated H-index: 18
(UC Davis: University of California, Davis),
Andrea Ferrero8
Estimated H-index: 8
(UC Davis: University of California, Davis)
+ 7 AuthorsRamsey D. Badawi29
Estimated H-index: 29
(UC Davis: University of California, Davis)
Sources
Abstract
Objective:Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) commonly affect the small joints of the wrist and hand. We evaluated the performance of a new, high-resolution extremity positron emission tomography (PET)/CT scanner for characterizing and quantifying pathologies associated with the two arthritides in the wrist and hand joints.Methods:Patients with RA or PsA underwent fluorine-18 fludeoxyglucose (18F-FDG) PET/CT wrist and hand imaging, respectively, on the high-resolution scanner. Calibrated CT images and co-registered PET images were reconstructed. PET/CT was derived for the radiocarpal and pisiform–triquetral compartments, joints with erosive changes, sites of synovitis or tenosynovitis and the nail bed and were correlated with clinical and MRI findings.Results:Significantly elevated 18F-FDG uptake was measured for the radiocarpal and pisiform–triquetral compartments and at sites of bone erosion, synovitis, pannus and oedema, compared with unaffected joints (p < 0.05) in patients with RA...
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