257 Single course of 5-fluorouracil treatment prevents new actinic keratoses for 6 to 12 months

Actinic keratoses (AKs) progress to squamous cell carcinoma at a rate of 0.1-0.6% per year and are a prevalent and costly public health concern. 5-fluorouracil (5-FU) cream is an effective AK treatment, but prior studies have not been designed to evaluate 5-FU for chemoprophylaxis. We sought to determine whether a single course of 5-FU reduced new AKs. We studied 319 participants enrolled in a double-blind placebo-controlled trial of a single...