Characteristics of Skin Inflammatory Cells Following Exposure of Mice to Sulfur Mustard

Sulfur mustard (SM) is a chemical warfare agent that causes skin damage characterized by inflammation and blistering. We investigated leukocyte infiltration into mouse skin after SM exposure. The dorsal skin of female SKH1-Hr hairless mice was treated with SM vapor and skin biopsies collected at 1, 3, 5, 7, 14 and 21 days. One day post SM, epidermal thickening and stratum corneum shedding were noted. This was associated with an accumulation of...