Prostate cancer induces C/EBPβ expression in surrounding epithelial cells which relates to tumor aggressiveness and patient outcome

Background Implantation of rat prostate cancer cells into the normal rat prostate results in tumor‐stimulating adaptations in the tumor‐bearing organ. Similar changes are seen in prostate cancer patients and they are related to outcome. One gene previously found to be upregulated in the non‐malignant part of tumor‐bearing prostate lobe in rats was the transcription factor CCAAT/enhancer‐binding protein‐β (C/EBPβ). Methods To explore this...