Targeted Delivery of Immunomodulators to Lymph Nodes
Abstract
Active-targeted delivery to lymph nodes represents a major advance toward more effective treatment of immune-mediated disease. The MECA79 antibody recognizes peripheral node addressin molecules expressed by high endothelial venules of lymph nodes. By mimicking lymphocyte trafficking to the lymph nodes, we have engineered MECA79-coated microparticles containing an immunosuppressive medication, tacrolimus. Following intravenous administration,...
Paper Details
Title
Targeted Delivery of Immunomodulators to Lymph Nodes
Published Date
May 10, 2016
Journal
Volume
15
Issue
6
Pages
1202 - 1213
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Notes
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