Baseline status and dose to the penile bulb predict impotence 1 year after radiotherapy for prostate cancer.

Published on Apr 14, 2016in Strahlentherapie Und Onkologie2.899
· DOI :10.1007/S00066-016-0964-1
Cesare Cozzarini43
Estimated H-index: 43
,
Tiziana Rancati27
Estimated H-index: 27
+ 8 AuthorsC. Fiorino7
Estimated H-index: 7
Sources
Abstract
Aim To assess the predictors of the onset of impotence 1 year after radiotherapy for prostate cancer.
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#1Wee Loon Ong (University of Cambridge)H-Index: 7
Last. Jeremy Millar (Monash University)H-Index: 29
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Abstract Background and purpose Erectile function (EF) is commonly affected following prostate cancer treatment. We aim to evaluate the long-term EF following seed brachytherapy (BT) treatment. Materials and methods The study consisted of 366 patients treated with BT at our institution, who completed the IIEF-5 questionnaire and reported no or mild erectile dysfunction (ED) pre-BT. The probability of EF preservation post-BT was estimated using the Kaplan–Meier methods. The difference in EF prese...
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#1V. CarilloH-Index: 9
#2Cesare CozzariniH-Index: 43
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Background and purpose: DUE01 is an observational study aimed at developing predictive models of genito-urinary toxicity of patients treated for prostate cancer with conventional (1.8–2 Gy/fr, CONV) or moderate hypo-fractionation (2.35–2.7 Gy/fr, HYPO). The current analysis focused on the relationship between bladder DVH/DSH and the risk of International Prostate Symptoms Score (IPSS) P 15/20 at the end of radiotherapy.
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#1E. Rivin del Campo (Institut Gustave Roussy)H-Index: 4
#2K. Thomas (UTSW: University of Texas Southwestern Medical Center)H-Index: 1
Last. Mack Roach (UCSF: University of California, San Francisco)H-Index: 88
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Erectile dysfunction after radiotherapy for prostate cancer: a model assesing the conflicting literature on dose–volume effects
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Purpose Within a multicenter study (DUE-01) focused on the search of predictors of erectile dysfunction and urinary toxicity after radiotherapy for prostate cancer, a dummy run exercise on penile bulb (PB) contouring on computed tomography (CT) images was carried out. The aim of this study was to quantitatively assess interobserver contouring variability by the application of the generalized DICE index. Methods and Materials Fifteen physicians from different Institutes drew the PB on CT images o...
26 CitationsSource
#1Alessandro MagliH-Index: 12
#2M. Giangreco (University of Udine)H-Index: 1
Last. S. FongioneH-Index: 1
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Purpose Erectile dysfunction is associated with all the common treatment options for prostate cancer. The aim of this research was to evaluate the relationship between erectile function and radiation dose to the penile bulb (PB) and other proximal penile structures in men receiving conformal radiotherapy (CRT) without hormonal therapy (HT) for prostate cancer, whose sexual function was known before treatment.
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#1Bradford S. Hoppe (UF: University of Florida)H-Index: 29
#2Romaine C. Nichols (UF: University of Florida)H-Index: 14
Last. Nancy P. Mendenhall (UF: University of Florida)H-Index: 66
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Erectile dysfunction (ED) is a critical health-related quality of life (HRQoL) outcome in men treated for prostate cancer and has been associated with depression and significant distress.1, 2 Many effective treatment options are available to men with prostate cancer, including surgery, external-beam radiotherapy (EBRT), and brachytherapy, and some men select treatment based on perceived side effect profiles, frequently focusing on urinary incontinence and ED. Several studies have investigated an...
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#1Lanea M.M. Keller (Fox Chase Cancer Center)H-Index: 5
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Objective To evaluate erectile function after high-dose radiotherapy for prostate cancer using the International Index of Erectile Function, Expanded Prostate Cancer Index Composite, and stamp test. Methods Men with favorable and intermediate-risk prostate cancer were assigned to receive prostate intensity-modulated radiotherapy (IMRT) versus an erectile tissue-sparing IMRT technique in a Phase III randomized, prospective study. The stamp test and International Index of Erectile Function and Exp...
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#1Lucia PernaH-Index: 17
#2Cesare CozzariniH-Index: 43
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Several investigations have recently suggested the existence of a correlation between the dose received by the penile bulb (PB) and the risk of erectile dysfunction (ED) after radical radiotherapy for clinically localized prostate carcinoma. A prospective multi-Institute study (DUE-01) was implemented with the aim to assess the predictive parameters of ED. Previously, an evaluation of inter-observer variations of PB contouring was mandatory in order to quantify its impact on PB dose-volume param...
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#1Mehrdad Alemozaffar (Harvard University)H-Index: 1
#1Mehrdad Alemozaffar (Harvard University)H-Index: 1
Last. Martin G. Sanda (Harvard University)H-Index: 71
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Results Two years after prostate cancer treatment, 368 (37% [95% CI, 34%-40%]) of all patients and 335 (48% [95% CI, 45%-52%]) of those with functional erections prior to treatment reported functional erections; 531 (53% [95% CI, 50%-56%]) of patients without penile prostheses reported use of medications or other devices for erectile dysfunction. Pretreatment sexual HRQOL score, age, serum prostate-specific antigen level, race/ethnicity, body mass index, and intended treatment details were assoc...
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#2Luca Incrocci (EUR: Erasmus University Rotterdam)H-Index: 38
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BACKGROUND: Erectile dysfunction (ED) is the most common side effect of prostate radiotherapy (RT), but reported rates over time and across modalities have varied widely. AIM: To evaluate the published literature between 2002 and 2018 for high quality data utilizing prospectively gathered patient-reported ED, and to summarize the challenges in reporting of RT-induced ED (RIED). METHODS: A PubMed search and literature review was performed to identify articles describing rates of ED before and aft...
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#1Julia Murray (ICR: Institute of Cancer Research)H-Index: 6
#2Sarah L. Gulliford (ICR: Institute of Cancer Research)H-Index: 23
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Abstract Background and purpose The penile bulb (PB) dose may be critical in development of post prostate radiotherapy erectile dysfunction (ED). This study aimed to generate PB dose constraints based on dose-volume histograms (DVHs) in patients treated with prostate radiotherapy, and to identify clinical and dosimetric parameters that predict the risk of ED post prostate radiotherapy. Materials and methods Penile bulb DVHs were generated for 276 patients treated within the randomised IGRT subst...
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#1F. Böckelmann (FAU: University of Erlangen-Nuremberg)H-Index: 1
#2M. Hammon (FAU: University of Erlangen-Nuremberg)H-Index: 1
Last. Florian Putz (FAU: University of Erlangen-Nuremberg)H-Index: 11
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Objective This study aimed to assess the reduction in dose to the penile bulb (PB) achieved by MRI-based contouring following drinking and endorectal balloon (ERB) instructions.
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#1A. NapieralskaH-Index: 7
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To compare the clinical outcome in prostate cancer patients treated with radiotherapy using two forms of image guidance: bone-based (BB) or fiducial-based (FB). This retrospective study consisted of 180 patients treated with kV-kV image-guided radiotherapy (IGRT) between the years 2008 and 2011. A total of 89 patients were aligned to pelvic bone (Group BB) and 91 patients to the fiducial implanted into prostate for image guidance (Group FB). Patients were treated to a total dose of 76 Gy in 38 f...
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#1Valeria LandoniH-Index: 20
#2Claudio FiorinoH-Index: 54
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Abstract This comprehensive review addresses most organs at risk involved in planning optimization for prostate cancer. It can be considered an update of a previous educational review that was published in 2009 (Fiorino et al., 2009). The literature was reviewed based on PubMed and MEDLINE database searches (from January 2009 up to September 2015), including papers in press; for each section/subsection, key title words were used and possibly combined with other more general key-words (such as ra...
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