von Willebrand factor multimerization and the polarity of secretory pathways in endothelial cells
Abstract
The von Willebrand factor (VWF) synthesized and secreted by endothelial cells is central to hemostasis and thrombosis, providing a multifunctional adhesive platform that brings together components needed for these processes. VWF secretion can occur from both apical and basolateral sides of endothelial cells, and from constitutive, basal, and regulated secretory pathways, the latter two via Weibel-Palade bodies (WPB). Although the amount and...
Paper Details
Title
von Willebrand factor multimerization and the polarity of secretory pathways in endothelial cells
Published Date
Jul 14, 2016
Journal
Volume
128
Issue
2
Pages
277 - 285
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