P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors

Volume: 36, Issue: 8, Pages: 2364 - 2376
Published: Feb 24, 2016
Abstract
Activation of visceral nociceptors by inflammatory mediators contributes to visceral hypersensitivity and abdominal pain associated with many gastrointestinal disorders. Purine and pyrimidine nucleotides (e.g., ATP and UTP) are strongly implicated in this process following their release from epithelial cells during mechanical stimulation of the gut, and from immune cells during inflammation. Actions of ATP are mediated through both ionotropic...
Paper Details
Title
P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors
Published Date
Feb 24, 2016
Volume
36
Issue
8
Pages
2364 - 2376
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