Pirfenidone inhibits fibrosis in foreign body reaction after glaucoma drainage device implantation

Published on Apr 15, 2016in Drug Design Development and Therapy4.162
路 DOI :10.2147/DDDT.S99957
Kyoung In Jung13
Estimated H-index: 13
(Catholic University of Korea),
Chan Kee Park28
Estimated H-index: 28
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Abstract
Background The aim of this study was to investigate the antiscarring effects of pirfenidone on foreign body reaction in a rabbit model of glaucoma drainage implant surgery.
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1996
1 Author (Massimo G. Bucci)
References48
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#1Jung Hwa NaH-Index: 12
#2Kyung Rim Sung (UOU: University of Ulsan)H-Index: 33
Last. Jung Il Moon (Catholic University of Korea)H-Index: 7
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Purpose The purpose of this study was to evaluate the antifibrotic effects of pirfenidone (PFD) on primary cultured human Tenon鈥檚 fibroblasts (HTFs) from primary open-angle glaucoma (POAG) eyes, compared to mitomicin C (MMC) and 5-fluorouracil (5-FU).
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#1Momoko Nakamura-Shibasaki (Hiroshima University)H-Index: 2
#2Ji-Ae Ko (Hiroshima University)H-Index: 16
Last. Yoshiaki Kiuchi (Hiroshima University)H-Index: 24
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Failure of surgery for glaucoma is usually due to post-surgical scarring (fibrosis), a process in which fibroblasts play a prominent role. We investigated the molecular mechanisms of such scarring by examining the expression of matrix metalloproteinases and cytokines in Tenon fibroblasts isolated from rats after glaucoma surgery. Filtration surgery was performed in one eye and implant surgery in the other; and Tenon fibroblasts were isolated from the tissue surrounding the bleb after surgery. Th...
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#1Kyoung In Jung (Catholic University of Korea)H-Index: 13
#2Seong-Beom Lee (Catholic University of Korea)H-Index: 15
Last. Chan Kee Park (Catholic University of Korea)H-Index: 28
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PURPOSE. To investigate the histopathology of the foreign body reaction (FBR) and the effect of aqueous humor on it in glaucoma drainage implant surgery. METHODS. A glaucoma drainage device was implanted into 20 New Zealand white rabbits. We monitored the histopathology of blebs at microscopic levels from 3 days to 8 weeks postoperatively. Hematoxylin and eosin staining, Masson鈥檚 trichrome staining, anti-actin and a鈥搒mooth muscle immunofluorescence staining, and antiproliferating cell nuclear an...
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#1Kyoung In Jung (Catholic University of Korea)H-Index: 13
#2Sung A. Lim (Catholic University of Korea)H-Index: 2
Last. Chan Kee Park (Catholic University of Korea)H-Index: 28
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Objective The current study investigated the internal structure of blebs using anterior-segment optical coherence tomography (AS-OCT) in patients who had undergone Ahmed glaucoma valve (AGV) (New World Medical Inc, Rancho Cucamonga, CA) implantation and compared the differences between successful and failed surgeries. Design Cross-sectional, observational study. Participants A total of 76 patients who had undergone AGV implantation. Methods The blebs after AGV implantation were examined using AS...
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#1Jun-Feng Chen (SEU: Southeast University)H-Index: 5
#2Hai Feng Ni (SEU: Southeast University)H-Index: 4
Last. Bi-Cheng Liu (SEU: Southeast University)H-Index: 32
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Tubulointerstitial macrophage infiltration is a hallmark of chronic kidney disease involved in the progression of renal fibrosis. Pirfenidone is a newly identified antifibrotic drug, the potential mechanism of which remains unclear. The aim of this study was to investigate the effects of pirfenidone on M1/M2 macrophage infiltration in nephrectomized rats. Nephrectomized rats were treated with pirfenidone by gavage for 12 wk. Twenty-four hour urinary protein, N -acetyl-尾-d-glycosaminidase (NAG) a...
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#1Wolfram Schmidt (University of Rostock)H-Index: 13
#2Christian KastnerH-Index: 5
Last. Klaus-Peter SchmitzH-Index: 32
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Glaucoma is a common cause of blindness in industrialized countries and is the most frequent cause of irreversible blindness worldwide. Since raised intraocular pressure (IOP) has been implicated as the major risk factor, the main goal of all glaucoma treatment is to reduce IOP sufficiently to prevent continuous irreversible retinal ganglion cell damage and progression of visual field loss. Pharmacological reduction of IOP is first-line therapy, followed by laser treatment of the trabecular mesh...
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#1Kyoung In Jung (Catholic University of Korea)H-Index: 13
#2Jun-Sub Choi (Catholic University of Korea)H-Index: 24
Last. Sun Young Shin (Catholic University of Korea)H-Index: 6
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Purpose: To evaluate the usefulness of an anti-transforming growth factor-尾 (TGF-尾) agent, pirfenidone (PFD) on postoperative inflammation and fibrosis following strabismus surgery in rabbits.Methods: Both eyes of 16 New Zealand white rabbits underwent reinsertion of the superior rectus muscle (SRM). After reinsertion of the SRM, PFD-loaded liposomes (0.5 mg/ml) were injected into the right eye (PFD group) and normal saline-loaded liposomes was injected into the left eye (control group), subconj...
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Purpose To report one-year results of the Tube Versus Trabeculectomy (TVT) Study. Design Multicenter randomized clinical trial. Methods setting: 17 Clinical Centers. study population: Patients 18 to 85 years of age who had previous trabeculectomy and/or cataract extraction with intraocular lens implantation and uncontrolled glaucoma with intraocular pressure (IOP) 鈮18 mm Hg and 鈮40 mm Hg on maximum tolerated medical therapy. interventions: 350 mm 2 Baerveldt glaucoma implant or trabeculectomy wi...
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#1Kyungsun Choi (KAIST)H-Index: 20
#2Kihwang LeeH-Index: 14
Last. Chulhee Choi (KAIST)H-Index: 50
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Purpose: Transforming growth factor-尾 (TGF-尾) plays a key role in transforming retinal pigment epithelial (RPE) cells into mesenchymal fibroblastic cells, which are implicated in proliferative vitreoretinopathy. Herein, we tested the effect of pirfenidone, a novel antifibrotic agent, on TGF-尾1-mediated fibrogenesis in the human RPE cell line ARPE-19. Methods: The effect of pirfenidone on the TGF-尾1-induced phenotype in ARPE-19 cells was measured with immunocytochemistry as the change in F-actin....
#1Masuyoshi Saito (TMU: Tokyo Medical University)H-Index: 8
#2Masashi Yamazaki (TMU: Tokyo Medical University)H-Index: 13
Last. Ryoji Tsuboi (TMU: Tokyo Medical University)H-Index: 50
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Keloid is a clinically intractable disease that causes disfigurement, itching, and pain due to abnormal proliferation of fibroblasts and production of collagen. Pirfenidone is a novel anti-fibrotic agent that inhibits the progression of fibrosis occurring in the keloid lesions of the lung and kidney. In order to examine whether pirfenidone has a therapeutic effect on keloid lesions, we prepared an in vitro wound contraction model with keloid fibroblasts. The gel contractility of a mixture of kel...
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#1Alexey L. Fayzullin (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 4
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Peri-implant fibrosis (PIF) increases the postsurgical risks after implantation and limits the efficacy of the implantable drug delivery systems (IDDS). Pirfenidone (PF) is an oral anti-fibrotic drug with a short ( 1100 渭m in control groups) approaching the intact derma thickness value (302 卤 15 渭m). In PLA@PF group, the implant biodegradation developed faster, while arginase-1 expression was suppressed in comparison with other groups. This study proves the feasibility of the local control of fi...
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#1Fu-Jun Zhu (Chinese PLA General Hospital)H-Index: 2
#2Yalin TongH-Index: 1
Last. Yong-ming Yao (Chinese PLA General Hospital)H-Index: 30
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Modulation of the key immune cell subsets by biomaterial has emerged as a potential target to promote tissue repair and regeneration. Based on calcium alginate (Alg) and glycol chitosan (GC), an injectable double-network (DN) hydrogel has been developed as a scaffold for cell delivery and cell cocultured system. Previous studies have documented the interaction between dendritic cells (DCs) and GC or Alg hydrogel, but the potential effect of DN hydrogel on activation of DCs still remains unclear....
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#1K. KasarH-Index: 1
#2T. Demir (脟anakkale Onsekiz Mart University)H-Index: 1
Last. S. Gungor KobatH-Index: 1
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Summary Purpose To investigate the effects of halofuginone and pirfenidone on wound healing in experimental glaucoma filtration surgery (GFS). Study Design Animal experimentation. Methods A total of 42 male New Zealand albino rabbits were separated into 6 equal groups. A limbal-based trabeculectomy was performed on 5 groups, and Group I (control group) underwent no surgery and received no postoperative medication. For Group II (sham group), 1 drop 0.9% NaCl was instilled qid for 14 days. For Gro...
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#1E. L. At鈥檏ovaH-Index: 4
#2Anatoly A. FedorovH-Index: 6
Last. N. N. KrakhovetskiyH-Index: 3
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One of the main reasons of failure of dacryocystorhinostomy (DCR) is cicatricial closure of the ostium. Finding a way to prevent this outcome remains one of the leading aims of research in dacryology. The effectiveness of the most widespread methods is often considered contradictory by various researchers. Pirfenidone is a small-molecule agent that demonstrated good antifibrotic effect and low toxicity in previous in vitro research. There haven't been any in vivo studies of its intraoperative us...
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Modulation of wound healing is one of the main challenges in glaucoma surgery. Modern antiproliferative agents used to reduce postoperative scarring are either insufficiently effective or inadequate in terms of safety. In the search for novel agents devoid of such drawbacks, specialists directed their attention to selective inhibitors of proinflammatory cytokines and growth factors. The article reviews pathophysiologic basis of wound healing, characteristics of inflammatory mediators affecting f...
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#1Kyoung In Jung (Catholic University of Korea)H-Index: 13
#2Jung Eun Woo (Catholic University of Korea)H-Index: 2
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A hypertensive phase frequently develops in the early postoperative period after glaucoma shunt operations. Anti-glaucoma eye drop use is essential when postoperative intraocular pressure (IOP) is not controlled. We investigated whether the use of early topical anti-glaucoma medication affects wound healing following glaucoma tube surgery. Eyes were randomly assigned to receive topical aqueous suppressant (timolol-dorzolamide fixed combination), prostaglandin (PG) analogue (travoprost), or norma...
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#1Hans D. Westermeyer (NCSU: North Carolina State University)H-Index: 8
#2Beth Salmon (NCSU: North Carolina State University)H-Index: 1
Last. Freya M. Mowat (NCSU: North Carolina State University)H-Index: 12
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OBJECTIVE: To evaluate tissue levels, safety, and efficacy of topical ophthalmic 0.5% and 1% pirfenidone in decreasing subconjunctival fibrosis. ANIMAL STUDIED: Twelve normal beagle dogs PROCEDURES: A 5聽脳聽1聽mm diameter silicone disk was implanted subconjunctivally in one eye, and then dogs were treated with topical 0.5% pirfenidone (n聽=聽9) in artificial tears or artificial tears alone (n聽=聽3) for 28聽days. To evaluate tissue drug levels, a single sample of tears, conjunctiva, and aqueous humor wa...
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#1Nadia Rios-Acosta (UM: University of Manitoba)
The fundament of glaucoma surgery is to artificially create an additional pathway for aqueous humor outflow, with a consequent lowering of IOP (Fig. 19.1).
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#1Thomas Stahnke (University of Rostock)H-Index: 8
#2Stefan SiewertH-Index: 4
Last. Andreas Wree (University of Rostock)H-Index: 27
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To prevent implant failure due to fibrosis is a major objective in glaucoma research. The present study investigated the antifibrotic effects of paclitaxel (PTX), caffeic acid phenethyl ester (CAPE), and pirfenidone (PFD) coated microstent test specimens in a rat model. Test specimens based on a biodegradable blend of poly(4-hydroxybutyrate) biopolymer and atactic poly(3-hydroxybutyrate) (at.P(3HB)) were manufactured, equipped with local drug delivery (LDD) coatings, and implanted in the subcuta...
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#1Lucienne Juillerat-Jeanneret (CHUV: University Hospital of Lausanne)H-Index: 34
#2John-David AubertH-Index: 32
Last. Dela Golshayan (UNIL: University of Lausanne)H-Index: 25
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Fibrosis is an inadequate response to tissue stress with very few therapeutic options to prevent its progression to organ dysfunction. There is an urgent need to identify drugs with a therapeutic potential for fibrosis, either by designing and developing new compounds or by repurposing drugs already in clinical use which were developed for other indications. In this Perspective, we summarize some pathways and biological targets involved in fibrosis development and maintenance, focusing on common...
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