Activating mutations of the stimulatory G protein in the McCune-Albright syndrome.

Volume: 325, Issue: 24, Pages: 1688 - 1695
Published: Dec 12, 1991
Abstract
Background. The McCune-Albright syndrome is a sporadic disease characterized by polyostotic fibrous dysplasia, cafe au lait spots, sexual precocity, and hyperfunction of multiple endocrine glands. These manifestations may be explained by a somatic mutation in affected tissues that results in activation of the signal-transduction pathway generating cyclic AMP (cAMP). We analyzed DNA from tissues of patients with the McCune-Albright syndrome for...
Paper Details
Title
Activating mutations of the stimulatory G protein in the McCune-Albright syndrome.
Published Date
Dec 12, 1991
Volume
325
Issue
24
Pages
1688 - 1695
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