Bone–cartilage interface

Published on Jan 1, 2015
· DOI :10.1016/B978-1-78242-301-0.00013-6
Nitya Ganesh4
Estimated H-index: 4
(Amrita Vishwa Vidyapeetham),
Shantikumar V. Nair75
Estimated H-index: 75
(Amrita Vishwa Vidyapeetham),
Lakshmi S. Nair41
Estimated H-index: 41
(University of Connecticut Health Center)
Articular cartilage lesion often results from trauma or diseases and is a major contributor to the onset of debilitating diseases such as osteoarthritis. Current repair strategies for chondral and osteochondral defects even though can improve the quality of the life of patients for short duration has significant disadvantages. Tissue engineering is emerging as a potential alternative strategy to support the regeneration of articular cartilage. The chapter presents a brief discussion of the structure of articular cartilage and the various biomaterials currently been considered for cartilage tissue regeneration.
📖 Papers frequently viewed together
4 Authors (Pierre Weiss, ..., Claire Vinatier)
7 Citations
36 Citations
#1Nora T. Khanarian (Columbia University)H-Index: 4
#2Jie JiangH-Index: 23
Last. Helen H. LuH-Index: 49
view all 5 authors...
Osteoarthritis is the leading cause of physical disability among Americans, and tissue engineered cartilage grafts have emerged as a promising treatment option for this debilitating condition. Currently, the formation of a stable interface between the cartilage graft and subchondral bone remains a significant challenge. This study evaluates the potential of a hybrid scaffold of hydroxyapatite (HA) and alginate hydrogel for the regeneration of the osteochondral interface. Specifically, the effect...
90 CitationsSource
#1Hua-Ding Lu (SYSU: Sun Yat-sen University)H-Index: 1
#2Huiqing Zhao (SYSU: Sun Yat-sen University)H-Index: 8
Last. Lulu Lv (SYSU: Sun Yat-sen University)H-Index: 5
view all 4 authors...
Abstract Gene therapy is a promising new treatment strategy for common joint-disorders such as osteoarthritis. The development of safe, effective, targeted non-viral gene carriers is important for the clinical success of gene therapy. The present work describes the use of hybrid hyaluronic acid (HA)/chitosan (CS) nanoparticles as novel non-viral gene delivery vectors capable of transferring exogenous genes into primary chondrocytes for the treatment of joint diseases. HA/CS plasmid–DNA nanoparti...
91 CitationsSource
#1Jiaan Zhou (SCUT: South China University of Technology)H-Index: 3
#2Caixia Xu (SCUT: South China University of Technology)H-Index: 4
Last. Yingjun Wang (SCUT: South China University of Technology)H-Index: 42
view all 9 authors...
Abstract Integrated, layered osteochondral (OC) composite materials and/or engineered OC grafts are considered as promising strategies for the treatment of OC damage. A novel biomimetic collagen–hydroxyapatite (COL–HA) OC scaffold with different integrated layers has been generated by freeze-drying. The capacity of the upper COL layer and the lower COL/HA layer to promote the growth and differentiation of human mesenchymal stem cells (hMSCs) into chondrocytes and osteoblasts respectively was eva...
79 CitationsSource
#1Omidreza Firuzi (Shiraz University of Medical Sciences)H-Index: 31
#2Ramin MiriH-Index: 38
Last. Luciano SasoH-Index: 52
view all 4 authors...
Reactive oxygen species (ROS) are widely believed to cause or aggravate several human pathologies such as neurodegenerative diseases, cancer, stroke and many other ailments. Antioxidants are assumed to counteract the harmful effects of ROS and therefore prevent or treat oxidative stress-related diseases. In this report, recent human studies exploring the efficiency of antioxidants in prevention and treatment of various diseases are reviewed. Few antioxidants including edaravone (for ischemic str...
282 CitationsSource
#1Jiangning Chen (NU: Nanjing University)H-Index: 36
#2Huan Chen (NU: Nanjing University)H-Index: 53
Last. Junfeng Zhang (NU: Nanjing University)H-Index: 32
view all 10 authors...
Engineering complex tissues is important but difficult to achieve in tissue regeneration. Osteochondral tissue engineering for the repair of osteochondral defect, involving simultaneous regeneration of bone and cartilage, has attracted considerable attention and also serves as an optimal model system for developing effective strategies aimed at regenerating complex tissues. In the present study, we formulated a bilayered gene-activated osteochondral scaffold consisting of plasmid TGF-β1-activate...
211 CitationsSource
#1Nathan Henry Dormer (KU: University of Kansas)H-Index: 11
#2Kamal F. Busaidy (University of Texas Health Science Center at Houston)H-Index: 5
Last. Michael S. Detamore (KU: University of Kansas)H-Index: 52
view all 4 authors...
Purpose Tissue engineering solutions focused on the temporomandibular joint (TMJ) have expanded in number and variety during the past decade to address the treatment of TMJ disorders. The existing data on approaches for healing small defects in the TMJ condylar cartilage and subchondral bone, however, are sparse. The purpose of the present study was thus to evaluate the performance of a novel gradient-based scaffolding approach to regenerate osteochondral defects in the rabbit mandibular condyle...
47 CitationsSource
#1Sumrita Bhat (IITK: Indian Institute of Technology Kanpur)H-Index: 10
#2Anuj Tripathi (IITK: Indian Institute of Technology Kanpur)H-Index: 14
Last. Ashok Kumar (IITK: Indian Institute of Technology Kanpur)H-Index: 88
view all 3 authors...
The study focuses on the synthesis of a novel polymeric scaffold having good porosity and mechanical characteristics synthesized by using natural polymers and their optimization for application in cartilage tissue engineering. The scaffolds were synthesized via cryogelation technology using an optimized ratio of the polymer solutions (chitosan, agarose and gelatin) and cross-linker followed by the incubation at sub-zero temperature (2128C). Microstructure examination of the chitosan – agarose – ...
167 CitationsSource
#1Oliver Schneider (ETH Zurich)H-Index: 10
#2Dirk MohnH-Index: 21
Last. Wendelin J. StarkH-Index: 79
view all 10 authors...
Background: The purpose of this preliminary study was to assess the in vivo performance of synthetic, cotton wool-like nanocomposites consisting of a biodegradable poly(lactide-co-glycolide) fibrous matrix and containing either calcium phosphate nanoparticles (PLGA/CaP 60:40) or silver doped CaP nanoparticles (PLGA/Ag-CaP 60:40). Besides its extraordinary in vitro bioactivity the latter biomaterial (0.4 wt% total silver concentration) provides additional antimicrobial properties for treating bon...
37 CitationsSource
Background: In recent years, there has been an increasing interest in and awareness of the importance of subchondral bone, for its role in the pathogenesis of articular surface damage and for the care that should be taken when treating such damage.Purpose: The objective of this pilot clinical study was to test the safety and performance of a newly developed type I collagen-hydroxyapatite nanostructured biomimetic osteochondral scaffold that aims to regenerate cartilage and subchondral bone.Study...
152 CitationsSource
#1Cevat Erisken (Stevens Institute of Technology)H-Index: 12
#2Dilhan M. Kalyon (Stevens Institute of Technology)H-Index: 46
Last. Jiahua Xu (Stevens Institute of Technology)H-Index: 3
view all 5 authors...
The ability to fabricate tissue engineering scaffolds containing systematic gradients in the distributions of stimulators provides additional means for the mimicking of the important gradients observed in native tissues. Here the concentration distributions of two bioactive agents were varied concomitantly for the first time (one increasing, whereas the other decreasing monotonically) in between the two sides of a nanofibrous scaffold. This was achieved via the application of a new processing me...
69 CitationsSource
Cited By0