Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease.
Abstract
Atherosclerosis, cancer, and various chronic fibrotic conditions are characterized by an increase in the migratory behavior of resident cells and the enhanced invasion of assorted exogenous cells across a stiffened extracellular matrix (ECM). This stiffened scaffold aberrantly engages cellular mechanosignaling networks in cells, which promotes the assembly of invadosomes and lamellae for cell invasion and migration. Accordingly, deciphering the...
Paper Details
Title
Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease.
Published Date
Jul 1, 2016
Journal
Volume
26
Issue
7
Pages
486 - 497
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History