Optimization of solid-self nanoemulsifying drug delivery system for solubility and release profile of clonazepam using simplex lattice design

The objective of the present work was to improve solubility and dissolution release properties of clonazepam (CNZ) from solid-self nanoemulsifying drug delivery system (S-SNEDDS). Liquid SNEDDS (L-SNEDDS) of CNZ was a system consisted of sunflower oil, Tween 80 and PEG 600 as vehicle, surfactant and co-surfactant, respectively. The L-SNEDDS were systematically optimized using simplex lattice design. The selected independent variables were % of...