Anti-stromal treatment together with chemotherapy targets multiple signalling pathways in pancreatic adenocarcinoma
Abstract
Stromal targeting for pancreatic ductal adenocarcinoma (PDAC) is rapidly becoming an attractive option, due to the lack of efficacy of standard chemotherapy and increased knowledge about PDAC stroma. We postulated that the addition of stromal therapy may enhance the anti-tumour efficacy of chemotherapy. Gemcitabine and all-trans retinoic acid (ATRA) were combined in a clinically applicable regimen, to target cancer cells and pancreatic stellate...
Paper Details
Title
Anti-stromal treatment together with chemotherapy targets multiple signalling pathways in pancreatic adenocarcinoma
Published Date
May 25, 2016
Journal
Volume
239
Issue
3
Pages
286 - 296
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